Biological effects of EV71 infection in neural cells

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Biological effects of EV71 infection in neural cells

Enterovirus 71 (EV71) can cause serious nervous system lesions but to date the pathogenesis has been unclear. Our results show that EV71 proliferates in the neural cells and leads to neural cell lesions. The study of the pathology of EV71 infection in neonatal rat brains shows that the invasive ability of EV71 to the nervous system in vivo may depend on many unknown factors.

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Inhibition of EV71 by curcumin in intestinal epithelial cells

EV71 is a positive-sense single-stranded RNA virus that belongs to the Picornaviridae family. EV71 infection may cause various symptoms ranging from hand-foot-and-mouth disease to neurological pathological conditions such as aseptic meningitis, ataxia, and acute transverse myelitis. There is currently no effective treatment or vaccine available. Various compounds have been examined for their ab...

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Enterovirus-71 (EV71) is a viral pathogen that causes severe cases of hand, foot and mouth disease (HFMD) among young children, with significant mortality. Effective vaccines against HFMD are urgently required. Several EV71 virus-like particle (VLP) vaccine candidates were found to be protective in the neonatal mouse EV71 challenge model. However, to what extent the VLP vaccine protects suscept...

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ژورنال

عنوان ژورنال: Journal of Biophysical Chemistry

سال: 2010

ISSN: 2153-036X,2153-0378

DOI: 10.4236/jbpc.2010.12014